Phenotypes and Genotypes: The Search for Influential Genes
Frommlet, Florian, Bogdan, Ma Gorzata, Ramsey, David
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
Կատեգորիաներ:
Տարի:
2016
Հրատարակչություն:
Springer
Լեզու:
english
Էջեր:
222
ISBN 10:
1447153103
ISBN 13:
9781447153108
Ֆայլ:
PDF, 3.78 MB
IPFS:
,
english, 2016